Date: 2024-06-19

Take a look at data extracted from previous trials and longitudinal studies

  • Hammitt et al.2022: MELODY (Phase III)
  • Simões et al. 2023: phase IIb + phase III
  • Ares-Gómez et al. 2024: longitudinal study in Spain


Use data from previous trials as priors to do VE estimation

Comparing:
* Original trial estimates; * Adjusted VE estimated from current case-control study (uninformative priors); * Adjusted VE estimated from current case-control study (trial data as informative priors)

Medically attended RSV LRTI (Hammitt et al)

  • extracted from case-control: RSV-related LRTI as cases vs. RSV- as controls
## Compiling model graph
##    Resolving undeclared variables
##    Allocating nodes
## Graph information:
##    Observed stochastic nodes: 2809
##    Unobserved stochastic nodes: 11
##    Total graph size: 31008
## 
## Initializing model
## 
## Compiling model graph
##    Resolving undeclared variables
##    Allocating nodes
## Graph information:
##    Observed stochastic nodes: 2811
##    Unobserved stochastic nodes: 15
##    Total graph size: 31035
## 
## Initializing model

Medically attended all-cause LRTI (Hammitt et al)

  • extracted from case-control: records with LRTI symptoms as cases vs. those without LRTI symptoms as controls
## Compiling model graph
##    Resolving undeclared variables
##    Allocating nodes
## Graph information:
##    Observed stochastic nodes: 3142
##    Unobserved stochastic nodes: 11
##    Total graph size: 34671
## 
## Initializing model
## 
## Compiling model graph
##    Resolving undeclared variables
##    Allocating nodes
## Graph information:
##    Observed stochastic nodes: 3144
##    Unobserved stochastic nodes: 15
##    Total graph size: 34698
## 
## Initializing model

Compare the results